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Atribuição de Bolsas de Investigação
| Projecto: |
SFRH/BPD/94312/2013 |
| Título: |
Biochemical, morphological and functional evaluation of breast cancer-induced muscle wasting: the role of exercise training |
| Tipo: |
Bolsa Post-doc |
| Nome: |
Ana Isabel Martins Novais Padrão |
| Orientador: |
José Alberto Duarte |
| Abstract: |
Skeletal muscle loss appears to be the most significant clinical event in cancer cachexia and is associated with a poor outcome. Among non-pharmacological interventions that may potentially attenuate muscle wasting in cancer patients is exercise training. Nevertheless, more data is needed to support this hypothesis. The present proposal aims to evaluate the effect of endurance training on cancer-induced muscle wasting. In this sense, we intend to assess: i) tumor-host interplay through the analysis of serum biochemical parameters, ii) muscle phenotype by MHC and metabolic profiling, iii) signaling pathways potentially activated in skeletal muscle by pro-inflammatory and wasting cytokines. All the methodologies are already implemented at CIAFEL-UP and QOPNA-UA. We believe that the integration of all data will allow to mechanistically advice endurance training as a non-pharmacological intervention to be included in the clinical management of cancer-induced muscle wasting. |
| Projecto: |
SFRH/BD/93281/2013 |
| Título: |
Effects of life-long physical exercise on brain function in Alzheimer disease and aging conditions - Relevance of mitochondrial-mediated mechanisms |
| Tipo: |
Bolsa de doutoramento |
| Nome: |
Telma Bernardo |
| Orientador: |
António Ascensão |
| Abstract: |
This project will analyze the effects of life-long physical activity on brain function in Alzheimer disease (AD) and aging with special reference to mitochondrial–mediating mechanisms. Behavioral tests, mitochondrial bioenergetics endpoints (oxygen consumption, transmembrane potential) and calcium movements will be performed. Markers of oxidative damage, mitochondrial dynamics, apoptosis and antioxidants, including Bax/Bcl2, SIRT3, p66Shc, MnSOD, aconitase, carbonyls, PGC-1a, Mfn, Drp 1, Fis-1, caspase 3/9 activities, and the mitochondrial permeability transition pore regulators F(1)F(0) ATP-synthase c subunit, ANT and cyclophilin D will be measured. With this project funded by FCT (PTDC/DTP/DES/1246/2012), important contributions to understand the mitochondrial mechanisms associated with the role of exercise to mitigate age- and AD-related brain dysfunction will be provided. Depending on the data obtained, it may be suggested that an active life-style during life course reduces brain mitochondrial dysfunction and cell death and thus should likely be advised against these pathophysiological conditions. |
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CANDIDATURAS PÓS-DOUTORAMENTOS CIAFEL-FADEUP |
| Projecto: |
PTDC/DES/098309/2008 |
| Título: |
Physical Activity and Early life risk factors for
obesity in childhood: A Longitudinal Study in Preschool Children aged 3 to 5 years-old |
| Coordenação: |
Prof. Doutor Jorge Mota |
| Anúncio: |
Download  |
| Projecto: |
CANDIDATURAS PÓS-DOUTORAMENTOS CIAFEL-FADEUP (Un. Inv. FCT) |
| Área: |
Qualidade de Vida e Factores Determinantes (Área 3) |
| Título: |
Envelhecimento |
| Palavras-chave: |
Factores Ambientais; Barreiras; Envolvimento Social; Factores Sócio-Económicos; Bem-Estar; Funcionalidade e mobilidade; |
| Projecto: |
CANDIDATURAS PÓS-DOUTORAMENTOS CIAFEL-FADEUP (Un. Inv. FCT) |
| Área: |
Avaliação da Composição Corporal (Área 2) |
| Título: |
Doenças Crónico-Degenerativas |
| Palavras-chave: |
Obesidade; Diabetes Tipo II; Sensibilidade à Insulina; Intolerância à Glicose; Alterações Hormonais; Metabolismo |
| Projecto: |
CANDIDATURAS PÓS-DOUTORAMENTOS CIAFEL-FADEUP (Un. Inv. FCT) |
| Área: |
Área funcional (Área 1) |
| Título: |
Reabilitação Cardíaca |
| Palavras-chave: |
Funcionalidade cardiovascular; Funcionalidade Muscular; Aptidão Cárdio respiratória; Alterações Hormonais; Metabolismo; Factores de Risco; Programas |
| Projecto: |
PTDC/DES/101333/2008 |
| IP: |
CIAFEL |
| Título: |
Cardiac autonomic function and cardiovascular risk factors in young adults. |
| Anúncio: |
Download |
| Projecto: |
PTDC/DES/108780/2008 |
| IP: |
CIAFEL |
| Título: |
CARDIOVASCULAR RISK FACTORS, FUNCTIONAL FITNESS AND HEALTH-RELATED QUALITY OF LIFE IN OLDER ADULTS: RELATIONSHIP AND TRAINING EFFECTS. |
| Anúncio: |
Download |
| Projecto: |
PTDC/DES/099018/2008 |
| IP: |
CIAFEL |
| Título: |
Actividade física objectivamente avaliada e obesidade em adolescentes: Estudo dos determinantes pessoais, sociais e ambientais. |
| Anúncio: |
Download |
| Projecto: |
PTDC/DES/098309/2008 |
| IP: |
CIAFEL |
| Título: |
Physical Activity and Early life risk factors for obesity in childhood: A Longitudinal Study in Preschool Children aged 3 to 5 years-old. |
| Anúncio: |
Download |
| Projecto: |
PTDC/DES/104518/2008 |
| IP: |
CIAFEL |
| Título: |
Actividade Física na população idosa; validação de pontos de corte específicos para acelerómetros através do consumo de oxigénio (VO2) ajustados à idade e género e a sua associação com a agregação de factores de risco
de DCV. |
| Anúncio: |
Download |
| Projecto: |
PTDC/DES/102094/2008 |
| IP: |
CIAFEL |
| Título: |
Body perceptions and
physical activity patterns of older adults. Analysis of the effects of a multicomponent exercise program
on functionality, cardiovascular health and physicality. |
| Anúncio: |
Download |
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